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Article

Time-resolved, integrated analysis of clonally evolving genomes.

PLoS genetics - 1 Dec 2023

Legrand Carine, Andriantsoa Ranja, Lichter Peter, Raddatz Günter, Lyko Frank

Abstract excerpt

Clonal genome evolution is a key feature of asexually reproducing species and human cancer development. While many studies have described the landscapes of clonal genome evolution in cancer, few determine the underlying evolutionary parameters from molecular data, and even fewer integrate theory with data. We derived theoretical results linking mutation rate, time, expansion dynamics, and biological/clinical...

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Identifiers

PMID: 38096267
DOI: 10.1371/journal.pgen.1011085
PMCID: PMC10754456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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