Article
Time-resolved, integrated analysis of clonally evolving genomes
2021-10-08
Abstract excerpt
Clonal genome evolution is a key aspect for parthenogenetic species and cancer. While many studies describe precise landscapes of clonal evolution in cancer, few determine the underlying evolutionary parameters from molecular data, and even fewer integrate theory with data. We derived theoretical results linking mutation rate, time, expansion dynamics, and clinical parameters. We then inferred time-resolved estima...
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Identifiers and source
- Literature Corpus work
- b1bf99cd-cc85-55fc-8a63-77de5486806d
- DOI
- 10.1101/2021.10.08.463633