Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion

13 Dec 2023

Abstract excerpt

Jagged1 (JAG1) is a Notch ligand that correlates with tumor progression. Not limited to its function as a ligand, JAG1 can be cleaved, and its intracellular domain translocates to the nucleus, where it functions as a transcriptional cofactor. Previously, we showed that JAG1 intracellular domain (JICD1) forms a protein complex with DDX17/SMAD3/TGIF2. However, the molecular mechanisms underlying JICD1-mediated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Developmental Biology and Gene Regulation
Share to Genetic factors in colorectal cancer
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38092725
DOI: 10.1038/s41419-023-06356-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasionPMID 38092725Read ↗

TGIF1-Twist1 axis in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

TWIST1 promotes invasion through mesenchymal change in human glioblastomaSemantic proximity Read ↗

Gamma synuclein is a novel Twist1 target that promotes TGF-β-induced cancer cell migration and invasionSemantic proximity Read ↗

TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growthSemantic proximity Read ↗

Epithelial–Mesenchymal Transition and Tumor Suppression Are Controlled by a Reciprocal Feedback Loop between ZEB1 and Grainyhead-like-2Semantic proximity Read ↗

Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other DiseasesSemantic proximity Read ↗

FOXD3 Modulates Migration through Direct Transcriptional Repression of TWIST1 in MelanomaSemantic proximity Read ↗

IKBIP is a novel EMT-related biomarker and predicts poor survival in gliomaSemantic proximity Read ↗

TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional RegulationSemantic proximity Read ↗

TWIST is expressed in human gliomas and promotes invasion.Semantic proximity Read ↗

The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem CellsSemantic proximity Read ↗

PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.