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Gamma synuclein is a novel Twist1 target that promotes TGF-β-induced cancer cell migration and invasion

24 May 2018

Abstract excerpt

Transforming growth factor β (TGF-β) is critical for embryonic development, adult tissue homeostasis, and tumor progression. TGF-β suppresses tumors at early stage, but promotes metastasis at later stage through oncogenes such as Twist1. Gamma-synuclein (SNCG) is overexpressed in a variety of invasive and metastatic cancer. Here, we show that TGF-β induces SNCG expression by Smad-Twist1 axis, thus promoting...

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PMID: 29795373
DOI: 10.1038/s41419-018-0657-z

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