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Article

TGIF1-Twist1 axis in pancreatic ductal adenocarcinoma

1 Jan 2020

Abstract excerpt

TG-interacting factor 1 (TGIF1) exerts inhibitory effects on transforming growth factor-beta (TGF-β) signaling by suppressing Smad signaling pathway at multiple levels. TGIF1 activity is important for normal embryogenesis and organogenesis, yet its dysregulation can culminate in tumorigenesis. For instance, increased expression of TGIF1 correlates with poor prognosis in triple-negative breast cancer patients, and...

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PMID: 33005315
DOI: 10.1016/j.csbj.2020.09.023

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