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Multi-omic profiling reveals age-specific blood biomarkers and aging-driven B cell remodeling in osteoarthritis

17 Jul 2025

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) pathogenesis involves age-related immune dysregulation, yet non-invasive diagnostic tools and mechanistic insights remain limited. METHODS: We integrated transcriptomic profiling of four OA-affected joint tissues with machine learning to identify potential peripheral blood biomarkers. Weighted gene co-expression network analysis was employed to explore gene modules and pathways...

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PMID: 40696927
DOI: 10.1097/js9.0000000000003076

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