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Article

Loss of Sc5d results in micrognathia due to a failure in osteoblast differentiation

11 Dec 2023

Abstract excerpt

INTRODUCTION: Mutations in genes related to cholesterol metabolism, or maternal diet and health status, affect craniofacial bone formation. However, the precise role of intracellular cholesterol metabolism in craniofacial bone development remains unclear. OBJECTIVE: The aim of this study is to determine how cholesterol metabolism aberrations affect craniofacial bone development. METHODS: Mice with a deficiency in...

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Share to Bone Metabolism and Diseases
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PMID: 38086515
DOI: 10.1016/j.jare.2023.12.008

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