Article
Sh3pxd2b mice are a model for craniofacial dysmorphology and otitis media.
PloS one - 1 Jan 2011
Yang Bin, Tian Cong, Zhang Zhi-guang, Han Feng-chan, Azem Rami, Yu Heping, Zheng Ye, Jin Ge, Arnold James E, Zheng Qing Y
Abstract excerpt
Craniofacial defects that occur through gene mutation during development increase vulnerability to eustachian tube dysfunction. These defects can lead to an increased incidence of otitis media. We examined the effects of a mutation in the Sh3pxd2b gene (Sh3pxd2b(nee)) on the progression of otitis media and hearing impairment at various developmental stages. We found that all mice that had the Sh3pxd2b(nee)...
Topics
- Animals
- Auditory Threshold
- Craniofacial Abnormalities
- Disease Models, Animal
- Ear, Middle
- Evoked Potentials, Auditory, Brain Stem
- Gene Expression Regulation
- Hearing Loss
- Humans
- Inflammation
- Inflammation Mediators