Article
Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders.
BMC medicine - 12 Dec 2023
Ye Junping, Huang Zhanwang, Li Qiyang, Li Zhongwei, Lan Yuting, Wang Zhongju, Ni Chaoying, Wu Xiaohui, Jiang Tingyun, Li Yujing, Yang Qiong, Lim Junghwa, Ren Cun-Yan, Jiang Meijun, Li Shufen, Jin Peng, Chen Jian-Huan, Zhao Cunyou
Abstract excerpt
BACKGROUND: Major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD) are complex genetic mental illnesses. Their non-Mendelian features, such as those observed in monozygotic twins discordant for SCZ or BPD, are likely complicated by environmental modifiers of genetic effects. 5-Hydroxymethylcytosine (5hmC) is an important epigenetic mark in gene regulation, and whether it is linked to...
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