The Drosophila NPY-like system protects against chronic stress–induced learning deficit by preventing the disruption of autophagic flux

Abstract excerpt

Chronic stress may induce learning and memory deficits that are associated with a depression-like state in Drosophila melanogaster . The molecular and neural mechanisms underlying the etiology of chronic stress–induced learning deficit (CSLD) remain elusive. Here, we show that the autophagy-lysosomal pathway, a conserved cellular signaling mechanism, is associated with chronic stress in Drosophila , as indicated...

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