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Epg5 links proteotoxic stress due to defective autophagic clearance and epileptogenesis in <i>Drosophila</i> and Vici Syndrome patients

2024-04-24

Abstract excerpt

Epilepsy is a common neurological condition that arises from dysfunctional neuronal circuit control due to either acquired or innate disorders. Autophagy is an essential neuronal housekeeping mechanism, which causes severe proteotoxic stress when impaired. Autophagy impairment has been associated to epileptogenesis through a variety of molecular mechanisms. Vici Syndrome (VS) is the paradigmatic congenital autopha...

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Literature Corpus work
5a3fac34-7b48-56da-8115-cc5979e788be
DOI
10.1101/2024.04.23.590762
Open publication

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Epg5 links proteotoxic stress due to defective autophagic clearance and epileptogenesis in <i>Drosophila</i> and Vici Syndrome patientsDOI 10.1101/2024.04.23.590762
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