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Autophagy in Schizophrenia: A Continuum From Developmental Vulnerability to Progressive Neuronal Stress? A Scoping Review

14 Jul 2025

Abstract excerpt

BACKGROUND AND HYPOTHESIS: Autophagy, the cell's primary degradation and recycling system, is essential for neuronal homeostasis. A structured synthesis of studies directly investigating autophagy in schizophrenia (SCZ) is lacking. This scoping review aimed to map the available evidence directly assessing autophagy processes in SCZ. STUDY DESIGN: We systematically searched Medline (via Ovid), Embase, and PsycINFO...

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PMID: 40802593
DOI: 10.1093/schbul/sbaf130

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