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Liberation of host heme by Clostridioides difficile- mediated damage enhances Enterococcus faecalis fitness during infection

11 Dec 2023

Abstract excerpt

ABSTRACT Toxin production by Clostridioides difficile damages the colonic epithelium and leads to a robust inflammatory response. This disruption of the epithelial barrier markedly alters the nutritional landscape in the C. difficile- infected gut. The impact of toxin-mediated nutritional remodeling during C. difficile infection (CDI) on resident microbiota remains largely unexplored. One group of opportunistic...

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PMID: 38078767
DOI: 10.1128/mbio.01656-23

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