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Article

Pathogenicity Locus, Core Genome, and Accessory Gene Contributions to Clostridium difficile Virulence

8 Aug 2017

Abstract excerpt

ABSTRACT Clostridium difficile is a spore-forming anaerobic bacterium that causes colitis in patients with disrupted colonic microbiota. While some individuals are asymptomatic C. difficile carriers, symptomatic disease ranges from mild diarrhea to potentially lethal toxic megacolon. The wide disease spectrum has been attributed to the infected host’s age, underlying diseases, immune status, and microbiome...

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PMID: 28790208
DOI: 10.1128/mbio.00885-17

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