Bw4 ligand and direct T-cell receptor binding induced selection on HLA A and B alleles.

Abstract excerpt

Introduction: The HLA region is the hallmark of balancing selection, argued to be driven by the pressure to present a wide variety of viral epitopes. As such selection on the peptide-binding positions has been proposed to drive HLA population genetics. MHC molecules also directly binds to the T-Cell Receptor and killer cell immunoglobulin-like receptors (KIR). Methods: We here combine the HLA allele frequencies...

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