Article
Protozoan-Derived Cytokine-Transgenic Macrophages Reverse Hepatic Fibrosis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Apr 2024
Chen Ying, Wang Jie, Zhou Nan, Fang Qi, Cai Haijian, Du Zhuoran, An Ran, Liu Deng, Chen Xuepeng, Wang Xinxin, Li Fangmin, Yan Qi, Chen Lijian, Du Jian
Abstract excerpt
Macrophage therapy for liver fibrosis is on the cusp of meaningful clinical utility. Due to the heterogeneities of macrophages, it is urgent to develop safer macrophages with a more stable and defined phenotype for the treatment of liver fibrosis. Herein, a new macrophage-based immunotherapy using macrophages stably expressing a pivotal cytokine from Toxoplasma gondii, a parasite that infects ≈ 2 billion people...
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