Article

<i>De novo</i> genesis of retinal ganglion cells by targeted expression of KLF4 <i>in vivo</i>

2018-08-17

Abstract excerpt

Retinal ganglion cell (RGC) degeneration is a hallmark of glaucoma, the most prevalent cause of irreversible blindness. Thus, innovative therapeutic strategies are needed to protect and replace these projection neurons. It has been shown that endogenous glial cells of the retina, Müller cells, can be directly reprogrammed into late-born retinal interneurons. However, since RGCs are the first neurons born during de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 232f4fb0-6096-5ce8-ae1d-94af80a0b8d9
DOI: 10.1101/393967

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>De novo</i> genesis of retinal ganglion cells by targeted expression of KLF4 <i>in vivo</i>DOI 10.1101/393967Read

Klf4 overexpression remodels chromatin to reprogram late retinal progenitors toward a retinal ganglion cell-like fateSemantic proximity Read

Regeneration of Functional Retinal Ganglion Cells by Neuronal Identity ReprogrammingSemantic proximity Read

Directed robust generation of functional retinal ganglion cells from Müller gliaSemantic proximity Read

Molecular regulation of retinal regeneration is context specificSemantic proximity Read

Evidence of Müller glia conversion into retina ganglion cells using Neurogenin2Semantic proximity Read

Preservation of vision after chemically induced retinal ganglion-like-cell transplantationSemantic proximity Read

Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway DevelopmentSemantic proximity Read

Stimulating the regenerative capacity of the human retina with proneural transcription factors in 3D culturesSemantic proximity Read

Genetic and epigenetic regulators of retinal Müller glial cell reprogrammingSemantic proximity Read

Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors.Semantic proximity Read

Sub-retinal transplantation of human iPSC-derived retinal sheets: A promising approach for the treatment of macular degenerationSemantic proximity Read

Cell transplantation of retinal ganglion cells derived from hESCsSemantic proximity Read