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Article

Stem cell transplantation rescued a primary open-angle glaucoma mouse model

28 Jan 2021

Abstract excerpt

Glaucoma is a leading cause of irreversible blindness. In this study, we investigated if transplanted stem cells are able to rescue a glaucoma mouse model with transgenic myocilin Y437H mutation and explored the possible mechanisms. Human trabecular meshwork stem cells (TMSCs) were intracamerally transplanted which reduced mouse intraocular pressure, increased outflow facility, protected the retinal ganglion...

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PMID: 33506763
DOI: 10.7554/elife.63677

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