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Article

Chronic Desipramine Reverses Deficits in Cell Activity, Norepinephrine Innervation, and Anxiety-Depression Phenotypes in Fluoxetine-Resistant cF1ko Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Jan 2024

Vahid-Ansari Faranak, Zahrai Amin, Daigle Mireille, Albert Paul R

Abstract excerpt

Selective serotonin (5-HT) reuptake inhibitors are only 30% effective for remission in subjects with major depression, and the best treatments for SSRI-resistant patients remain unclear. To model SSRI resistance, we used cF1ko mice with conditional deletion of the repressor Freud-1/CC2D1A in adult 5-HT neurons. Within weeks, this deletion leads to overexpression of 5-HT1A autoreceptors, reduced serotonergic...

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Identifiers

PMID: 38050173
DOI: 10.1523/JNEUROSCI.1147-23.2023
PMCID: PMC10860653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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