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Article

tRNA therapeutics for genetic diseases.

Nature reviews. Drug discovery - 1 Feb 2024

Coller Jeff, Ignatova Zoya

Abstract excerpt

Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their therapeutic potential for the treatment of genetic diseases - primarily those associated with a mutation altering mRNA translation - has gained significant attention. Engineering tRNAs to readthrough nonsense mutation-associated premature termination of mRNA translation can restore protein synthesis and function. In...

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Identifiers

PMID: 38049504
DOI: 10.1038/s41573-023-00829-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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