Article

Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma

2018-08-07

Abstract excerpt

Psychiatric diseases have a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance alone but to also involve epigenetic factors in germ cells 1,2 . Initial evidence suggested that sperm RNA is causally linked 2,3 to the transmission of symptoms induced by traumatic experiences. Here we show that alterations in long RNA in sperm contribute to the inheritance of specific tr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7833c9fe-4299-56ca-b451-5ad0c18317ce
DOI: 10.1101/386037

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal traumaDOI 10.1101/386037Read

Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal traumaSemantic proximity Read

A novel mode of communication between blood and the germline for the inheritance of paternal experiencesSemantic proximity Read

Small Noncoding RNAs Contribute to Sperm Oxidative Stress-Induced Programming of Behavioral and Metabolic Phenotypes in Offspring.Semantic proximity Read

Alterations in sperm RNAs persist after alcohol cessation and correlate with epididymal mitochondrial dysfunctionSemantic proximity Read

Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic InformationSemantic proximity Read

Exposure to childhood maltreatment is associated with changes in sperm small non-coding RNA and DNA methylation profilesSemantic proximity Read

Germ Cell Drivers: Transmission of Preconception Stress Across GenerationsSemantic proximity Read

Role of small RNAs harbored by sperm in embryonic development and offspring phenotype.Semantic proximity Read

Paternal transmission of early life traumatization through epigenetics: Do fathers play a role?Semantic proximity Read

Differential microRNAs in human serum and sperm after childhood trauma with potential implications for offspring healthSemantic proximity Read

Epididymal glucocorticoid receptors promote intergenerational transmission of paternal stressSemantic proximity Read

Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders.Semantic proximity Read