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Detecting EGFR gene amplification using a fluorescence in situ hybridization platform based on digital microfluidics.

Talanta - 1 Mar 2024

Shen Chuanjie, Zhan Cheng, Tong Zhaoduo, Yin Hao, Hui Jianan, Qiu Shihui, Li Qiushi, Xu Xin, Ma Hui, Wu Zhenhua, Shi Nan, Mao Hongju

Abstract excerpt

Signal transduction mediated by epidermal growth factor receptor (EGFR) gene affects the proliferation, invasion, metastasis, and angiogenesis of tumor cells. In particular, non-small cell lung cancer (NSCLC) patients with increased in copy number of EGFR gene are often sensitive to tyrosine kinase inhibitors. Despite being the standard for detecting EGFR amplification in the clinic, fluorescence in situ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38042143
DOI: 10.1016/j.talanta.2023.125444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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