Article
Fundamental insights into autosomal dominant polycystic kidney disease from human-based cell models.
Pediatric nephrology (Berlin, Germany) - 1 Oct 2019
Weydert Caroline, Decuypere Jean-Paul, De Smedt Humbert, Janssens Peter, Vennekens Rudi, Mekahli Djalila
Abstract excerpt
Several animal- and human-derived models are used in autosomal dominant polycystic kidney disease (ADPKD) research to gain insight in the disease mechanism. However, a consistent correlation between animal and human ADPKD models is lacking. Therefore, established human-derived models are relevant to affirm research results and translate findings into a clinical set-up. In this review, we give an extensive...
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