Article
Clinical characteristics of a large familial cohort with Medullary thyroid cancer and germline Cys618Arg RET mutation in an Israeli multicenter study.
Frontiers in endocrinology - 1 Jan 2023
Rosenblum Rachel Chava, Hirsch Dania, Grozinsky-Glasberg Simona, Benbassat Carlos, Yoel Uri, Ishay Avraham, Zolotov Sagit, Bachar Gideon, Banne Ehud, Levy Sigal, Twito Orit
Abstract excerpt
Objective: To determine genealogical, clinical and pathological characteristics of a cohort with Cys618Arg mutation from an Israeli multicenter MTC study. Methods: Retrospective database analysis examining RET mutations and comparing Cys618Arg and Cys634Arg/Thr/Tyr subgroups. Results: Genetic testing was performed in 131/275 MTC patients (47.6%). RET mutations were found in 50/131 (38.2%), including Cys618Arg...
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