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Article

Medullary Thyroid Carcinoma: Survival Analysis and Evaluation of Mutation-Specific Immunohistochemistry in Detection of Sporadic Disease.

World journal of surgery - 1 May 2018

Jayakody S, Reagh J, Bullock M, Aniss A, Clifton-Bligh R, Learoyd D, Robinson B, Delbridge L, Sidhu S, Gill A J, Sywak M

Abstract excerpt

INTRODUCTION: Medullary thyroid cancer (MTC) is a rare tumour of neuroendocrine origin with a more aggressive profile than differentiated thyroid cancer. Familial cases of MTC are associated with RET mutations whilst RAS mutations appear to be a frequent finding in RET negative tumours. The aims of this study were to analyse survival outcomes in MTC and to evaluate the role of RAS immunohistochemistry in the...

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Identifiers

PMID: 29484475
DOI: 10.1007/s00268-018-4551-8

Genes

RET

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