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Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF

1 Jan 2023

Abstract excerpt

Abstract In amyotrophic lateral sclerosis, a disease driven by abnormal transactive response DNA-binding protein of 43 kDa aggregation, CSF may contain pathological species of transactive response DNA-binding protein of 43 kDa contributing to the propagation of pathology and neuronal toxicity. These species, released in part by degenerating neurons, would act as a template for the aggregation of physiological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38025276
DOI: 10.1093/braincomms/fcad306

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