Article

A non-human primate model of Amyotrophic Lateral Sclerosis

2025-10-27

Abstract excerpt

<h4>SUMMARY</h4> Approximately 97% of patients with amyotrophic lateral sclerosis (ALS) have cytoplasmic mislocalization and aggregation of the ubiquitous nuclear protein, TDP-43. Current rodent models of this disease fail to replicate the progressive motor weakness and characteristic histopathology, possibly because of fundamental neuroanatomical and genetic differences between rodents and humans. In this study,...

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Literature Corpus work: 26cc5ded-0bd8-57b5-9fb2-7bbbcb9a05c2
DOI: 10.1101/2025.10.27.684759

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