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Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease

2 Nov 2023

Abstract excerpt

Alzheimer's disease (AD) is characterized by the accumulation of misfolded amyloid-beta and tau proteins. Autophagy acts as a proteostasis process to remove protein clumps, although it progressively weakens with aging and AD, thus facilitating the accumulation of toxic proteins and causing neurodegeneration. This review examines the impact of impaired autophagy on the progression of AD disease pathology. Under...

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PMID: 38020769
DOI: 10.3389/fnagi.2023.1281338

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