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Autophagy in Alzheimer’s disease

30 Jun 2010

Abstract excerpt

Autophagy is a degradation pathway for the turnover of dysfunctional organelles or aggregated proteins in cells. Extensive literature exists supporting a causative role of mitochondrial dysfunction and amyloid-beta protein in the pathogenesis of Alzheimer's disease (AD). Furthermore, a link between mitochondrial dysfunction, amyloid-beta levels and autophagy has been reported to occur in AD. However, it is not...

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PMID: 20586699
DOI: 10.1586/ern.10.84

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