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Deciphering the role of extrachromosomal circular DNA in adipose stem cells from old and young donors

28 Nov 2023

Abstract excerpt

Abstract Background The functional impairment of adipose stem cells (ASCs) during aging limits their clinical transformation. Studies have shown that extrachromosomal circular DNAs (eccDNAs) are associated with tumor progression and cell aging, but the roles of eccDNAs in ASCs remain unknown. Method We conducted Circle sequencing (Circle-seq) to identify eccDNAs in ASCs isolated from young and old donors. The...

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PMID: 38017497
DOI: 10.1186/s13287-023-03575-2

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