Increased expression of Mycobacterium tuberculosis Rv3737 gene associated with low-level amikacin resistance.

Abstract excerpt

INTRODUCTION: As an infectious disease, tuberculosis (TB) poses a serious threat to public health. Although amikacin (AMK) is an important antibiotic for the treatment of drug-resistant TB, its resistance mechanisms are not fully understood. METHODS: To investigate the role of Rv3737 gene on AMK drug susceptibility, a Mycobacterium tuberculosis (M.tb) Rv3737 knockout strain (H37Rv△Rv3737) and a Mycobacterium...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amikacin
• Share to Antitubercular Agents