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Article

Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 May 1998

Alangaden G J, Kreiswirth B N, Aouad A, Khetarpal M, Igno F R, Moghazeh S L, Manavathu E K, Lerner S A

Abstract excerpt

An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9593173
DOI: 10.1128/AAC.42.5.1295
PMCID: PMC105813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9593173-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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