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Article

Inhibition of microfold cells ameliorates early pathological phenotypes by modulating microglial functions in Alzheimer's disease mouse model.

Journal of neuroinflammation - 27 Nov 2023

Kim Namkwon, Ju In Gyoung, Jeon Seung Ho, Lee Yeongae, Jung Min-Ji, Gee Min Sung, Cho Jae Seok, Inn Kyung-Soo, Garrett-Sinha Lee Ann, Oh Myung Sook, Lee Jong Kil

Abstract excerpt

BACKGROUND: The gut microbiota has recently attracted attention as a pathogenic factor in Alzheimer's disease (AD). Microfold (M) cells, which play a crucial role in the gut immune response against external antigens, are also exploited for the entry of pathogenic bacteria and proteins into the body. However, whether changes in M cells can affect the gut environments and consequently change brain pathologies in AD...

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Identifiers

PMID: 38012646
DOI: 10.1186/s12974-023-02966-9
PMCID: PMC10680211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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