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Alterations of Spatial Memory and Gut Microbiota Composition in Alzheimer’s Disease Triple-Transgenic Mice at 3, 6, and 9 Months of Age

11 May 2023

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurological disease. Gut microbial dysbiosis is associated with AD. This study involves the comparative assessment of spatial learning, β-amyloid peptide accumulation, and fecal microbiota alterations in 3×Tg-AD mice from 3 age groups: AD asymptomatic stage (3 m), presymptomatic stage (6 m), and the symptomatic stage of AD (9 m). We demonstrate that spatial memory...

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PMID: 37169734
DOI: 10.1177/15333175231174193

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