Article

Modulation of Alzheimer’s Disease Brain Pathology in Mice by Gut Bacterial Deletion: The Role of Il-17a and Microglial MyD88

2023-12-06

Abstract excerpt

Gut bacteria regulate brain pathology of Alzheimer’s disease (AD) patients and animal models; however, the underlying mechanism remains unclear. In this study, 3-month-old APP-transgenic female mice with and without knock-out of Il-17a gene, or haploinsufficiency of MyD88 in microglia were treated with antibiotics-supplemented or normal drinking water for 2 months. Antibiotic treatment eradicated gut bacteria, pa...

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Literature Corpus work: 9d0796cd-7f38-5026-a39b-edb2121b79b2
DOI: 10.1101/2023.12.06.570400

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