Article

The gut microbiota affects amyloid deposition in Alzheimer’s disease models by suppressing immune-mediated Aβ clearance

2022-10-10

Abstract excerpt

<title>Abstract</title> <p>The gut microbiota and innate immune system play critical roles in Alzheimer’s disease (AD). <italic>Bacteroides</italic> is elevated in AD patients and correlates with cerebrospinal fluid levels of Aβ and tau. We found that increased Aβ plaques in <italic>Bacteroides fragilis</italic>-treated APP/PS1-21 mice were associated with altered cortical expression Aβ processing genes. <italic>...

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Literature Corpus work: 7f45c9a8-668b-54f8-8207-6a9c5326f5ca
DOI: 10.21203/rs.3.rs-2110304/v1

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