Article
Association of colitis with gut-microbiota dysbiosis in clathrin adapter AP-1B knockout mice
24 Mar 2020
Abstract excerpt
Inflammatory bowel disease results from alterations in the immune system and intestinal microbiota. The role of intestinal epithelial cells (IECs) in maintaining gut homeostasis is well known and its perturbation often causes gastrointestinal disorders including IBD. The epithelial specific adaptor protein (AP)-1B is involved in the establishment of the polarity of IECs. Deficiency of the AP-1B μ subunit...
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