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NTNH protein: more than a bodyguard for botulinum neurotoxins

27 Nov 2023

Abstract excerpt

As one of the most fatal substances, botulinum neurotoxins (BoNTs) have never acted solo to accomplish their formidable missions. Most notably, nontoxic nonhemagglutinin (NTNH), a protein co-secreted with BoNT by bacteria, plays critical roles to stabilize and protect BoNT by tightly associating with it to form the minimal progenitor toxin complex (M-PTC). A new cryo-EM structure of the M-PTC of a BoNT-like toxin...

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PMID: 38009421
DOI: 10.1111/febs.17004

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