Article
Detection of the JAK2 V617F Mutation in Urinary Cell-free DNA in Patients with Myeloproliferative Neoplasms.
Internal medicine (Tokyo, Japan) - 15 Jul 2024
Hosoi Hiroki, Hori Yoshikazu, Fukutsuka Katsuhiro, Osuga Mitsuo, Koh Yasuhiro, Mushino Toshiki, Hanaoka Nobuyoshi, Yamamoto Nobuyuki, Ohno Hitoshi, Sonoki Takashi
Abstract excerpt
Objective Testing for the Janus activating kinase 2 (JAK2) V617F mutation is important for diagnosing and treating myeloproliferative neoplasms (MPNs). Recently, urine cell-free DNA (ucfDNA) was reported to be useful for detecting tumor-specific gene mutations in several solid tumors. However, its utility in detecting such mutations in hematological malignancies has not yet been assessed. In this study, we...
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