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Article

Sugar transporter SLC45 gene family members: roles in malignant tumors and research progress.

Molecular biology reports - 12 Jan 2026

Xu Yuance, Sun Danting, Wang Chao, Yao Qin

Abstract excerpt

The SLC45 family emerges as a proton-coupled sugar transport system that complements the classical SGLT (SLC5) and GLUT (SLC2) transporters in mammals. This review synthesizes recent advances on four family members (SLC45A1–A4), covering their structural features (12-pass transmembrane topology with a pH-sensing cytoplasmic loop), genomic organization across chromosomes 1p36.1, 5p13.3, 1q32.1, and 8q24.3, and...

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Identifiers

PMID: 41524821
DOI: 10.1007/s11033-026-11433-6

Genes

SLC45A1
SLC45A3
SLC45A4
MYC
SLC45A2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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