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SARS-CoV-2 Evolution: Immune Dynamics, Omicron Specificity, and Predictive Modeling in Vaccinated Populations.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Oct 2024

Zhang Xiaohan, Li Mansheng, Zhang Nana, Li Yunhui, Teng Fei, Li Yongzhe, Zhang Xiaomei, Xu Xingming, Li Haolong, Zhu Yunping, Wang Yumin, Jia Yan, Qin Chengfeng, Wang Bingwei, Guo Shubin, Wang Yajie, Yu Xiaobo

Abstract excerpt

Host immunity is central to the virus's spread dynamics, which is significantly influenced by vaccination and prior infection experiences. In this work, we analyzed the co-evolution of SARS-CoV-2 mutation, angiotensin-converting enzyme 2 (ACE2) receptor binding, and neutralizing antibody (NAb) responses across various variants in 822 human and mice vaccinated with different non-Omicron and Omicron vaccines is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39206813
DOI: 10.1002/advs.202402639
PMCID: PMC11516136

Genes

ACE2

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