Article

Protein-glass microenvironments define electron transfer vulnerability in Leigh syndrome

2026-06-09

Abstract excerpt

Leigh syndrome is the most common pediatric mitochondrial encephalopathy, yet the physical mechanisms linking diverse pathogenic mutations to respiratory-chain failure remain poorly understood. Here we show that Leigh syndrome mutations are not randomly distributed within human mitochondrial Complex I but are preferentially enriched near the electron-transfer axis connecting flavin mononucleotide and iron–sulfur c...

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Literature Corpus work: f3528a43-36c6-5709-994a-e5ded6acd41b
DOI: 10.64898/2026.06.04.730076

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