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Article

Mitochondrial DNA mutation pathogenicity score and neurocognitive performance in persons with HIV.

Mitochondrion - 1 Jan 2024

Volpe Karen E, Samuels David C, Elson Joanna L, Steyn Jannetta S, Gebretsadik Tebeb, Ellis Ronald J, Heaton Robert K, Kallianpur Asha R, Letendre Scott, Hulgan Todd

Abstract excerpt

BACKGROUND: Mitochondrial DNA (mtDNA) genetic variation is associated with neurocognitive (NC) impairment (NCI) in people with HIV (PWH). Other approaches use sequence conservation and protein structure to predict the impact of mtDNA variants on protein function. We examined predicted mtDNA variant pathogenicity in the CHARTER study using MutPred scores, hypothesizing that persons with higher scores (greater...

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Identifiers

PMID: 37989461
DOI: 10.1016/j.mito.2023.11.003
PMCID: PMC10872545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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