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Engineered extracellular vesicles for delivering functional Cas9/gRNA to eliminate hepatitis B virus cccDNA and integration

20 Nov 2023

Abstract excerpt

The persistence of HBV covalently closed circular DNA (cccDNA) and HBV integration into the host genome in infected hepatocytes pose significant challenges to the cure of chronic HBV infection. Although CRISPR/Cas9-mediated genome editing shows promise for targeted clearance of viral genomes, a safe and efficient delivery method is currently lacking. Here, we developed a novel approach by combining light-induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37982370
DOI: 10.1080/22221751.2023.2284286

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