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Article

Identification and characterization of calreticulin as a novel plasminogen receptor.

The Journal of biological chemistry - 1 Jan 2024

Bharadwaj Alamelu G, Okura Gillian C, Woods John W, Allen Erica A, Miller Victoria A, Kempster Emma, Hancock Mark A, Gujar Shashi, Slibinskas Rimantas, Waisman David M

Abstract excerpt

Calreticulin (CRT) was originally identified as a key calcium-binding protein of the endoplasmic reticulum. Subsequently, CRT was shown to possess multiple intracellular functions, including roles in calcium homeostasis and protein folding. Recently, several extracellular functions have been identified for CRT, including roles in cancer cell invasion and phagocytosis of apoptotic and cancer cells by macrophages....

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Identifiers

PMID: 37979915
DOI: 10.1016/j.jbc.2023.105465
PMCID: PMC10770727

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