Article
Direct Detection of Low Abundance Genes of Single Point Mutation.
Nano letters - 10 Nov 2021
Mishra Sourav, Jeon Jinseong, Kang Jun-Kyu, Song Sang-Hyun, Kim Tae-You, Ban Changill, Choi Hayoung, Kim Yonggoo, Kim Myungshin, Park Joon Won
Abstract excerpt
Cell-free DNA (cfDNA) analysis, specifically circulating tumor DNA (ctDNA) analysis, provides enormous opportunities for noninvasive early assessment of cancers. To date, PCR-based methods have led this field. However, the limited sensitivity/specificity of PCR-based methods necessitates the search for new methods. Here, we describe a direct approach to detect KRAS G12D mutated genes in clinical ctDNA samples...
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