Article
Hepatocellular Carcinomas with Concomitant Mutations of TERT, TP53, and CTNNB1: Is There a Role for Artificial Intelligence?
Critical reviews in oncogenesis - 1 Jan 2023
Chillotti Stefano, Maloberti Thais, Degiovanni Alessio, Malvi Deborah, D'Errico Antonia, de Biase Dario, Vasuri Francesco
Abstract excerpt
TP53, CTNNB1, and TERT-promoter mutations are the most common driver mutations in hepatocellular carcinoma (HCC). The morphological and genetical HCC heterogeneities are difficult to discriminate by the eye of the pathologist. Here, we describe two rare cases of HCC with simultaneous co-mutation of all three of genes, which represent a poorly described occurrence in the literature. In these two cases, areas with...
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