Article
The ploidy conveyor of mature hepatocytes as a source of genetic variation.
Nature - 7 Oct 2010
Duncan Andrew W, Taylor Matthew H, Hickey Raymond D, Hanlon Newell Amy E, Lenzi Michelle L, Olson Susan B, Finegold Milton J, Grompe Markus
Abstract excerpt
Mononucleated and binucleated polyploid hepatocytes (4n, 8n, 16n and higher) are found in all mammalian species, but the functional significance of this conserved phenomenon remains unknown. Polyploidization occurs through failed cytokinesis, begins at weaning in rodents and increases with age. Previously, we demonstrated that the opposite event, ploidy reversal, also occurs in polyploid hepatocytes generated by...
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