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Article

Pathological polyploidy in liver disease

22 May 2015

Abstract excerpt

The composition of the liver changes dramatically with age. Hepatocytes in young individuals are relatively small and uniform in size. In contrast, adult hepatocytes vary considerably in cell and nuclear size, number of nuclei per cell and DNA content per nucleus (1, 2). Many of these striking age-associated morphological changes are attributed to hepatic polyploidy, a numerical change in the entire complement of...

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PMID: 25998371
DOI: 10.1002/hep.27908

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