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Article

Escitalopram population pharmacokinetics and remedial strategies based on CYP2C19 phenotype.

Journal of affective disorders - 1 Feb 2024

Liu Xin, Ju Gehang, Huang Xinyi, Yang Wenyu, Chen Lulu, Li Chao, He Qingfeng, Xu Nuo, Zhu Xiao, Ouyang Dongsheng

Abstract excerpt

BACKGROUND AND PURPOSE: CYP2C19 is a key factor influencing escitalopram (SCIT) exposure. However, different studies reported various results. This study aims to develop a population pharmacokinetic (popPK) model characterizes the disposition of SCIT in the Chinese population. Based on the popPK model, the study simulates non-adherence scenarios and proposes remedial strategies to facilitate SCIT personalized...

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Identifiers

PMID: 37949237
DOI: 10.1016/j.jad.2023.11.016

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